Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

In a new study, stem cell scientists at the Lund University, Sweden, explore the role of non-coding regions of the genome—previously deemed to be functionless “junk” DNA—and find humans and ...

There are some genes that can promote cancer; they are sometimes called oncogenes, and in tumor cells, mutations are often found in these genes. When they are functioning normally, oncogenes are often ...

Almost 1,500 genes have been implicated in intellectual disabilities; yet for most people with such disabilities, genetic causes remain unknown. Perhaps this is in part because geneticists have been ...

From the twists of the double helix to the vast diversity captured in pangenomes, our understanding of DNA is expanding beyond a static code. Researchers are uncovering the hidden influence of ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Much of the "junk" DNA in Drosophila shows signs of either negative or positive selection, according to a study in this week's Nature. An analysis by Peter Andolfatto of the University of California, ...

There was a time not long ago when biomedical research and industry were almost exclusively focused on proteins and the genes that encode them. Once termed “junk”, the non-coding regions of the genome ...

The diversity of facial shapes in birds and mammals is due to variations in non-coding DNA sequences Same genes, different ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...