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Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
BMJ

Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies

6 Health and Social Research Center, Universidad de Castilla La-Mancha, Cuenca, Spain Objective To examine the predictive validity of field-based muscular strength tests in relation to incident ...
The American Journal of Managed Care

Pivotal Studies in Cardiac Prevention Highlight Power of Cohorts

The Framingham Heart Study identified key cardiovascular risk factors and developed the Framingham risk score, significantly impacting preventive cardiology. Future research in Framingham includes ...
BMJ Open

Physical and mental health of ethnic minority service personnel in the UK Armed Forces: a retrospective pooled cross-sectional analysis

Objectives To assess physical and mental symptoms by ethnicity of a UK Armed Forces cohort. Design A retrospective, pooled ...