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2026 MLB picks for Tue., Apr. 21 from proven model

Cardinals vs. Marlins prediction, odds, time: 2026 MLB picks for Wednesday, April 22 from proven model

National League squads conclude a three-game series on Wednesday's MLB schedule as the Miami Marlins host the St. Louis Cardinals.

SportsLine · 1d

MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Tuesday, April 21 from a daily Fantasy pro

· 11h · on MSN

Where to watch Houston Astros vs Cleveland Guardians: TV channel, start time, streaming for Apr. 22

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Guardians lineup, live score updates tonight vs. Houston Astros

The reigning American League Central Division champion Cleveland Guardians open a three-game series with the Houston Astros tonight.

· 6h

Guardians vs. Astros MLB player props and odds - Wednesday, April 22

· 14h

Guardians and Astros play to determine series winner

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Astros vs. Guardians Game Thread: Game 25, 4/21/2026

RHP Ryan Weiss will make his second start of the season tonight.

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Astros vs Guardians Prediction, Picks & Odds for Today's MLB Game

· 1d

Guardians score tonight vs. Astros. How Houston shut down Cleveland

SportsLine

MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, April 22 from a daily Fantasy pro

All 30 MLB teams are in action on Wednesday's MLB schedule, but half-a-dozen of them take place in the afternoon. Even with that, the MLB DFS

Daily MLB Expert Picks & Baseball Predictions April 21

Daily MLB expert picks and moneyline, run line, and Over/Under predictions for April 21, featuring the Phillies, Orioles, and Braves.

Baseball America

MLB Predictions 2026: World Series Picks, Standings Preview & More

With the 2026 MLB season set to begin next week, Baseball America has been busy previewing the upcoming campaign with a series of crystal ball predictions on the sport’s biggest storylines, breakout players, award races and more. Below, you’ll find our ...